相关实验视频
Updated: Jul 12, 2025
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
1.7K
与无塑性甲状腺癌生存相关的因素:来自ENDOCAN-TUTHYREF网络的多中心研究
Arnaud Jannin1,2, Fabiola Giudici3,4, Christelle de la Fouchardière5
1CHU Lille, Department of Endocrinology, Diabetology, and Metabolism, Lille, France.
Thyroid : official journal of the American Thyroid Association
|October 19, 2023
概括
无塑性甲状腺癌 (ATC) 的存活率受到几个因素的影响. 多模式治疗,更好的性能状态和特定的瘤类型改善了结果,而晚期和更高的中性粒细胞与淋巴细胞比率表明预后更差.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 无塑性甲状腺癌 (ATC) 是一种罕见且具有攻击性的甲状腺癌,其生存率通常很低.
- 了解影响ATC总生存时间 (OS) 的因素对于改善患者管理和结果至关重要.
- 现有的关于ATC生存异质性的数据仍然有限.
研究的目的:
- 鉴定和评估与被诊断患有形甲状腺癌 (ATC) 的患者的整体存活率 (OS) 相关的因素.
- 分析来自法国大型国家队列的现实数据,以了解ATC的预后指标.
- 调查治疗方式和特定患者/瘤特征对ATC存活率的影响.
主要方法:
- 这是一项多中心的回顾性队列研究,涉及360名在2010年至2020年期间被诊断患有ATC的患者.
- 来自法国ENDOCAN-TUTHYREF网络的数据.
- 多变量考克斯比例危险模型用于分析与整体存活 (OS) 相关的因素.
主要成果:
- 平均生存期为6.8个月. 与改善的生存状况显著相关的因素包括东部合作性瘤学小组的绩效状态0-1,IVb阶段,以及多模式治疗 (手术和化疗放射治疗).
- 纯ATC (p-ATC) 和中性粒细胞与淋巴细胞比率 (NLR) >5.05独立地与明显更糟糕的生存状况相关.
- 在接受多模式治疗的小组患者中观察到长期存活.
结论:
- 独立预测ATC中改善OS的关键因素包括良好的表现状态,较不晚的疾病阶段,多模式治疗,同步转换ATC (st-ATC) 和较低的中性粒细胞与淋巴细胞比率 (NLR).
- 多模式治疗策略与在选择的ATC患者中显著改善生存结果有关.
- 这些发现强调了综合治疗方法和预后标记在治疗形甲状腺癌中的重要性.
相关概念视频
01:21Cancer Survival Analysis
357
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
357
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K