老年人多发性硬化症:一个回顾性队列研究
Anne Zinganell1, Georg Göbel2, Klaus Berek1
1Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Journal of neurology
|October 19, 2023
概括
这项研究表明,伴随性疾病,金字塔/小脑症状和频繁复发是老年多发性硬化症 (MS) 患者的不良预后指标. 这些因素对于了解代表性不足的人群中疾病进展至关重要.
科学领域:
- 神经学 神经学
- 临床研究 临床研究
- 老年病的医生 老年病的医生
背景情况:
- 对老年多发性硬化症 (MS) 患者的疾病过程,预后和治疗的理解有限.
- 老年多发性硬化症患者在临床试验中往往代表性不足.
研究的目的:
- 描述老年多发性硬化患者的疾病进展,包括残疾和复发.
- 量化疾病修饰疗法 (DMT) 的使用情况,并确定在这个人口群体中进展的并发症和风险因素.
主要方法:
- 对1200名年龄在55岁以上的奥地利MS患者进行了回顾性研究.
- 从15个多发性硬化中心收集的数据,包括人口统计,症状,复发,残疾,DMT和并发性疾病.
主要成果:
- 观察时间的中位数为17.1年;80%的人有复发发病.
- 伴随性疾病的数量,金字塔/小脑症状,以及更高的复发率与更糟糕的结局有关.
- 每个额外的并发症都会使达到6的扩展残疾状况尺度 (EDSS) 的风险增加22%.
结论:
- 伴随性疾病,金字塔/小脑症状和复发频率是老年多发性硬化症患者不良预后因素.
- 研究结果解决了有关该群体疾病过程和预后的知识差距.
- 结果可能会为未来的治疗策略和老年多发性硬化症患者的临床试验设计提供信息.
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