双A对神经系统的影响:一篇综述更新
Henrique Eloi Costa1,2, Elisa Cairrao3,4
1CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal.
Archives of toxicology
|October 19, 2023
概括
双甲 (BPA) 是一种内分泌干扰化学物质,会引起显著的神经毒性. 暴露会对大脑结构和功能产生负面影响,并增加成人和儿童的神经系统疾病的风险.
科学领域:
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 双A (BPA) 是一种广泛生产的合成化合物,存在于塑料和树脂中.
- BPA作为一种内分泌干扰化学物质 (EDC),干扰荷尔蒙功能.
- 它与雌激素受体的结合引发了对潜在的神经效应的担忧.
研究的目的:
- 审查最近关于暴露于Bisphenol A (BPA) 的神经毒性影响的研究.
- 巩固关于BPA对中枢神经系统的影响的发现.
- 突出BPA在神经疾病发展中的作用.
主要方法:
- 关于BPA神经毒性的最新科学研究的文献综述.
- 对实验和流行病学数据的分析.
- 对BPA分子,细胞和行为影响的研究结果的综合.
主要成果:
- 暴露于BPA会诱导大脑的结构和分子变化,包括氧化应激,改变基因/蛋白质表达和神经递质干扰.
- 它导致神经炎症,兴奋毒性,血脑屏障损伤,神经元亡和髓化受损.
- 乙与神经血管 (中风) 和神经退行性疾病 (阿尔茨海默氏症,帕金森症) 的风险增加有关.
- 流行病学数据将BPA与儿童的神经发育障碍相关联,如ADHD,ASD,抑郁症和认知缺陷.
结论:
- 通过促进大脑损伤和功能障碍,BPA暴露显著影响神经健康.
- 它会增加一系列严重的神经和神经发育障碍的风险.
- 进一步的研究对于充分阐明BPA诱导的神经毒性的机制及其对人类健康的影响至关重要.
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