前-状变化与行为变异前性痴呆症的冷漠程度相关
Neeraj Upadhyay1,2, Annika Spottke3,4, Anja Schneider3,5
1Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany. Neeraj.upadhyay@ukbonn.de.
Brain imaging and behavior
|October 19, 2023
概括
行为变异前性痴呆症 (bvFTD) 显示了大脑的结构和功能变化,特别是在前性性区域. 这些变化与冷漠的严重程度相关,突出了它们在bvFTD症状中的作用.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 认知神经科学 认知神经科学
背景情况:
- 行为变异前性痴呆症 (bvFTD) 与结构性和功能性大脑变化有关.
- 多式神经成像方法可以更深入地了解bvFTD神经心理症状的神经相关性.
研究的目的:
- 为了调查bvFTD患者的结构异常 (皮层厚度和皮层下体积) 和功能连接 (FC).
- 探索这些神经成像发现与临床/神经心理结果,特别是冷漠之间的关系.
主要方法:
- 多中心研究将37名bvFTD患者与37名健康对照人进行比较,使用结构性MRI (皮层厚度,皮层下体积).
- 使用静止状态fMRI在从结构变化区域播种的子队列 (22bvFTD,22对照) 中进行全脑FC分析.
- 从神经精神病学库存问卷中成像数据和冷漠度得分之间的相关性.
主要成果:
- bvFTD患者表现出前额和部区域皮质厚度降低,皮质下体积减少 (基底,乳头,海马,杏仁体).
- 在背上条纹体和左尾部中额头,面体和前额状区域,以及白体和小脑之间观察到CF的减少.
- 增加的FC在左侧中间状回环和状回环,尾状核和胰岛,杏仁体和状回环之间被发现.
- 前额区域的皮层厚度和尾状核体积与冷漠度的严重程度有负相关性.
结论:
- 多模式结构和功能神经成像显示了bvFTD中前-上网络的显著变化.
- 这些前-三角形结构和功能偏差与bvFTD患者的冷漠程度有关.
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