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Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
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与斑块相关的脱细化性脑膜炎.

Alireza Hedayatfar1,2, Pasha Anvari3, C P Herbort4,5

  • 1Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Sattar khan St., Niayesh Ave, Tehran, 14455-364, Iran. alireza.hedayatfar@gmail.com.

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PubMed
概括
此摘要是机器生成的。

脱皮化斑块相关性脑膜炎 (DPU) 通常影响女性,呈现为慢性中间性脑膜炎. 患有DPU的患者患多发性硬化症 (MS) 的风险更高,应避免使用抗TNF治疗.

关键词:
光素血管学 光素血管学多发性硬化症是多发性硬化症.视网膜血管炎 视网膜血管炎尿道炎,前面的尿道炎尿道炎,中间的尿道炎.

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科学领域:

  • 眼科医生 眼科 眼科
  • 神经学 神经学
  • 免疫学 免疫学 免疫学

背景情况:

  • 脱皮化斑块相关性脑膜炎 (DPU) 是一种独特的脑膜炎子集.
  • DPU患者在MRI上表现出中枢神经系统脱髓化斑块,但不符合多发性硬化症 (MS) 的标准.

研究的目的:

  • 描述DPU的临床和光素血管学 (FA) 特征.
  • 区分DPU与已建立的MS,并确定相关的风险因素和结果.

主要方法:

  • 对被诊断患有DPU的波斯患者进行了回顾性观察性研究.
  • 纳入标准:没有多发性硬化症的诊断,排除了其他类型的卵膜炎病因,并进行了至少2年的随访.
  • 数据收集包括临床发现,眼部特征,神经状态和FA成像.

主要成果:

  • 在最初的40名DPU患者中,8名 (20%) 后来符合MS标准.
  • 剩下的32名患者 (93.8%为女性,平均年龄为36.3岁) 主要患有双边慢性粒状中间性脑膜炎 (90.6%).
  • 常见的眼部发现包括颗粒状角质沉物 (97.7%),囊性黄斑胀 (35.7%) 和视神经炎 (8.9%). 光素血管学显示光盘泄漏 (81.5%) 和外围视网膜周围血管泄漏 (76.9%).

结论:

  • DPU通常表现为慢性,双边,粒状中间性脑膜炎,主要发生在女性身上,往往没有神经症状.
  • 视觉预后通常是有利的,在2年的随访期间有所改善.
  • DPU患者患MS的风险增加,因此不应接受抗TNF治疗.