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与斑块相关的脱细化性脑膜炎

Alireza Hedayatfar^1,2, Pasha Anvari³, C P Herbort^4,5

¹Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Sattar khan St., Niayesh Ave, Tehran, 14455-364, Iran. alireza.hedayatfar@gmail.com.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

|October 19, 2023

概括

脱皮化斑块相关性脑膜炎 (DPU) 通常影响女性,呈现为慢性中间性脑膜炎. 患有DPU的患者患多发性硬化症 (MS) 的风险更高,应避免使用抗TNF治疗.

科学领域:

眼科医生眼科眼科
神经学神经学
免疫学免疫学免疫学

背景情况:

脱皮化斑块相关性脑膜炎 (DPU) 是一种独特的脑膜炎子集.
DPU患者在MRI上表现出中枢神经系统脱髓化斑块,但不符合多发性硬化症 (MS) 的标准.

研究的目的:

描述DPU的临床和光素血管学 (FA) 特征.
区分DPU与已建立的MS,并确定相关的风险因素和结果.

主要方法:

对被诊断患有DPU的波斯患者进行了回顾性观察性研究.
纳入标准:没有多发性硬化症的诊断,排除了其他类型的卵膜炎病因,并进行了至少2年的随访.
数据收集包括临床发现,眼部特征,神经状态和FA成像.

主要成果:

在最初的40名DPU患者中,8名 (20%) 后来符合MS标准.
剩下的32名患者 (93.8%为女性,平均年龄为36.3岁) 主要患有双边慢性粒状中间性脑膜炎 (90.6%).
常见的眼部发现包括颗粒状角质沉物 (97.7%),囊性黄斑胀 (35.7%) 和视神经炎 (8.9%). 光素血管学显示光盘泄漏 (81.5%) 和外围视网膜周围血管泄漏 (76.9%).

结论:

DPU通常表现为慢性,双边,粒状中间性脑膜炎,主要发生在女性身上,往往没有神经症状.
视觉预后通常是有利的,在2年的随访期间有所改善.
DPU患者患MS的风险增加,因此不应接受抗TNF治疗.

关键词:

光素血管学光素血管学多发性硬化症是多发性硬化症.视网膜血管炎视网膜血管炎尿道炎,前面的尿道炎尿道炎,中间的尿道炎.

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