在Helicobacter pylori感染和先前感染的患者之间胃瘤的临床病理学差异:多中心回顾分析
Satoshi Kotani1, Kotaro Shibagaki2, Noriyuki Hirahara3
1Department of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Journal of gastroenterology
|October 19, 2023
概括
之前没有感染过Hp的患者的胃瘤正在增加,但不如HP感染病例那么恶性. 建议进一步研究Hp-naïve个体的成本效益查.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 在日本,Helicobacter pylori (Hp) 素的个体中,胃瘤的发病率不断上升.
- 减少HP感染的流行率有助于这一趋势.
- 对于HP感染和HP无感染的胃瘤之间的临床病理学差异的理解有限.
研究的目的:
- 调查和比较Hp感染的胃瘤 (HpIGNs) 和Hp-naïve胃瘤 (HpNGNs) 的临床病理特征.
- 阐明这两个群体之间的特征和恶性潜在的差异.
主要方法:
- 在10年内对966名患有1131例胃部发育不良或癌症的患者进行了回顾性多中心研究.
- 在HpIGN和HpNGN病例之间比较临床病理特征.
- 分析包括患者人口统计,瘤位置,大小,组织学和入侵状态.
主要成果:
- 在更年轻,更多的女性患者中,HpNGNs发生,主要在近腹部,并且比HpIGNs小.
- 两组都主要包括差异化类型,但HpNGN的入侵性癌症和淋巴血管入侵率明显较低.
- 几乎所有HpNGNs都在早期被诊断出来,与晚期发现的HpIGNs显著比例形成鲜明对比.
结论:
- 没有感染过HP的胃瘤正在增加,但与感染过HP的胃瘤相比,其恶性性质较低.
- 这些发现表明,需要审查Hp-naïve人群内镜胃癌查的成本效益.
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