老年人的运动认知风险和发病性痴呆症
Jeehae Chung1, Seonjeong Byun2
1Industry-Academic Cooperation Foundation, The Catholic University of Korea, Seoul, Korea.
JAMA network open
|October 19, 2023
概括
运动认知风险 (MCR),一种先发性痴呆综合征,有效估计老年人痴呆风险. 使用简单测试修改的MCR显示发生痴呆的风险增加了2倍,这表明它作为查工具的实用性.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 运动认知风险 (MCR) 是一种新的综合征,表明痴呆的风险增加.
- 对于全国性痴呆症发病率的MCR,特别是修改版的预测有效性仍然未得到充分探索.
研究的目的:
- 评估修改的运动认知风险 (MCR) 综合征,包括定时起床和一腿站立测试,与单个组件相比,改善痴呆风险预测.
- 为了评估MCR和事件痴呆症在一个大规模的全国性队列之间的关联.
主要方法:
- 一项全国范围的队列研究,对来自韩国国家过渡年龄查计划 (2009-2013) 的66岁以上的1,137,530名个人进行了调查.
- 定义了修改的MCR亚型 (定时起床和起床或一腿站立障碍与主观认知衰退).
- 考克斯比例危险回归分析用于检查MCR和事件痴呆症之间的关联,平均随访时间为7.02年.
主要成果:
- 1.4%和2.9%的参与者分别满足了定时起床和一腿站立的MCR亚型的标准.
- 患有MCR的参与者表现出发生性痴呆的风险大约是2倍 (aHR从2.03到2.05).
- 修改后的MCR显示,与单独的认知或运动组件相比,发生性痴呆的调整后危险比率更高.
结论:
- 改性运动认知风险综合征是一种实际的查工具,用于估计60多岁中期的个人痴呆风险.
- 这些发现表明,MCR对预测痴呆风险的个人认知或运动评估具有附加有效性.
- 需要对MCR的临床和神经生物学基础进行进一步的研究.
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