交联式X射线成像:一种用于同时获得定量和诊断数字减去血管图的方法
Joseph F Whitehead1, Carson A Hoffman2, Martin G Wagner2
1Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Medical physics
|October 19, 2023
概括
这项研究引入了一种交联式X射线成像技术,在定量数字减去血管造影 (qDSA) 过程中降低辐射剂量,同时实现同时诊断成像. 该方法成功量化了血液速度,对准确度的影响最小.
科学领域:
- 医疗成像医学成像
- 干预性放射学 干预性放射学
- 生物医学工程 生物医学工程
背景情况:
- 当前流量改变血管造影手术缺乏精确的定量终点.
- 定量数字减去血管学 (qDSA) 提供了手术内血液速度测量,但使用高剂量的辐射.
- 现有的qDSA协议 (30/秒) 超过诊断DSA的辐射水平 (高达4/秒).
研究的目的:
- 为了展示一个交叉的X射线成像方法,以减少高率qDSA的辐射剂量.
- 为了能够同时获取低剂量,高率的qDSA图像和低率的诊断DSA图像.
- 为了促进血液速度量化和血管形态评估,用单次对比剂注射.
主要方法:
- 开发了一种交叉的X射线成像协议,将低剂量,高速率与高剂量,低速率结合起来.
- 使用原型X射线系统评估了可行性,并在流量幻影研究中进行了评估.
- 两种低剂量 (LD1,LD2) 和一种常规 (全剂量) qDSA 协议与超声波测量进行了比较.
主要成果:
- 间隔协议实现了显著的剂量率降低:LD1 (-67.7%) 和LD2 (-85.5%).
- 速度测量显示与超声波有很强的一致性,LD1 LOA [0.3,6.9] cm/s和LD2 LOA [-2.5,5.5] cm/s.
- 观察到 qDSA 和超声速之间的高相关性 (r2 > 0.98) 在两个交叉协议之间.
结论:
- 间接的X射线成像方法有效地降低了qDSA程序期间的辐射剂量.
- 同时获取定量速度数据和诊断形态图像是可以实现的.
- 这种方法提高了流量改变血管造影干预的安全性和效率.
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