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瘤侵袭和体静止素受体亚型之间的相关性在壮病中

Shaolin Zhang^1,2, Shun Yao¹, Jinping Chen¹

¹1Department of Neurosurgery, Center for Pituitary Tumor Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

Journal of neurosurgery

|October 19, 2023

概括

低索马托斯坦素受体2 (SSTR2) 表达在瘤中与瘤入侵相关,并预测对索马托斯坦素类似物 (SSA) 的反应较差. SSTR2水平可以帮助管理术后残留瘤.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
分子生物学分子生物学

背景情况:

在体育瘤中,体育类受体 (SSTR) 亚型的表达会影响对体育类类似物 (SSA) 的治疗反应.
在体育瘤中SSTRs和瘤侵入性的关系尚不清楚.
瘤的侵入性可能会影响SSA治疗的疗效.

研究的目的:

为了研究SSTR亚型和瘤入侵体育瘤之间的相关性.
检查瘤侵入性和对SSAs的药理反应之间的关联.
为了确定潜在的生物标志物来管理体育瘤.

主要方法:

对102名经过手术的壮病患者进行了回顾性分析.
瘤的分类为非侵入性 (Knosp等级0-2) 和侵入性 (Knosp等级3-4).
评估SSTR表达 (SSTR1-3,SSTR5) 和对SSAs的反应 (IGF-1,GH水平,瘤体积减少).
对SSTR2和瘤入侵进行接收器操作特征 (ROC) 曲线分析.

主要成果:

侵入性瘤较大,与非侵入性瘤相比,SSTR2表达显著降低 (p < 0.001).
侵入性组对SSA的反应较差 (36.4%),而非侵入性组 (91.7%) 的反应较差 (p < 0.001).
较低的SSTR2mRNA水平与瘤入侵有很强的关联 (AUC0.805,p < 0.0001).

结论:

瘤入侵在体育瘤中与SSTR2表达有负相关性.
侵入性瘤中较低的SSTR2水平可能解释了对SSA治疗的反应减少.
SSTR2 作为一个潜在的生物标志物,用于管理术后残留体育瘤.

关键词:

亚克罗梅加利症是什么下垂体外科手术是一种手术.对索马托斯塔丁类 analog 的反应.索马托斯坦素受体亚型在人体生长中,人体内生长.瘤的入侵瘤的入侵

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