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在微流体装置中的可 perfusable 微血管网络上的皮层球体.

Teal Russell1, Qassim Dirar1, Yan Li2

  • 1Fostering Innovation Through Biosystems for Enhanced Scientific Technologies (FIT BEST) Laboratory, Department of Chemical, Biological, and Bio Engineering, College of Engineering, North Carolina A&T State University, Greensboro, NC, United States of America.

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概括
此摘要是机器生成的。

研究人员开发了一个微流体平台,以创建血管化的人类大脑球形. 这种3D模型模仿大脑发育,为疾病建模和药物查提供了一个新的工具.

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科学领域:

  • 神经科学是一个神经科学.
  • 生物技术是生物技术.
  • 生物工程是生物工程.

背景情况:

  • 人类诱导多能干细胞 (hiPSC) 衍生的脑球体模型人类大脑发育.
  • 现有的模型缺乏可 perfusable 微血管网络,这对于恒常是必不可少的.
  • 血管生成由血管生成因子调节,可以创建3D血管网络.

研究的目的:

  • 开发一个微流体平台,用于创建血管化的3D大脑球形.
  • 调查影响血管造血血管网络形成的因素.
  • 展示一种用于大脑研究和药物发现的新型体外模型.

主要方法:

  • 用3D皮质球形构建了一个微流体装置.
  • 使用度梯度驱动的血管因子诱导血管发芽.
  • 研究了PMA,内皮细胞定向,ECM和球状集成对血管化的影响.

主要成果:

  • 成功创建了一个可 perfusable 微血管网络与皮质球形集成.
  • 确定了成功血管生成和血管网络形成的关键因素.
  • 展示了一个无膜,可扩展的体外平台的概念证明.

结论:

  • 微流体系统可以产生血管化的脑球体,改善体外建模.
  • 这个平台为研究脑部疾病和查药物提供了一种经济有效的,动物测试的替代方案.
  • 开发的模型有可能用于神经科学研究中的高通量应用.