患有Plasmodium falciparum疟疾的患者的肠道损伤和肠道微生物群
Natthida Sriboonvorakul1, Kesinee Chotivanich1,2, Udomsak Silachamroon1
1Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
PLoS pathogens
|October 19, 2023
概括
严重的Falciparum疟疾会损害肠道,改变肠道微生物并增加感染风险. 了解这种肠道寄生虫相互作用是打击严重疟疾和相关并发症的关键.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 严重的Falciparum疟疾病理生理学涉及复杂的宿主-寄生虫-微生物相互作用.
- 感染Plasmodium falciparum可以导致肠道损伤和增加肠道透性.
- 在严重疟疾患者中观察到肠道微生物组合和多样性的改变.
研究的目的:
- 为了审查寄生虫诱导的肠道损伤在Plasmodium falciparum疟疾.
- 在严重疟疾期间分析人类肠道微生物群组成的变化.
- 探索肠道微生物群在疟疾病理生理学中的作用.
主要方法:
- 审查现有的流行病学和实验研究.
- 在肠道健康的背景下,对宿主寄生虫相互作用的分析.
- 检查Plasmodium falciparum对肠道微血管结构的影响.
主要成果:
- P. falciparum感染会导致微循环阻塞,可能导致肠道损伤和肠道泄漏.
- 严重的疟疾病例显示出更高的并发性细菌病率和改变的肠道微生物群.
- 在严重疟疾患者中,致病生物的丰富和微生物代谢物的检测表明它们在并发症中的作用.
结论:
- 肠道微生物群的改变,包括病原生物丰富,与严重的疟疾病理生理学有关.
- 微生物代谢产物可能会导致临床并发症,如代谢性化症.
- 需要进一步针对肠道微生物群的干预研究来确定因果关系.
相关概念视频
01:28Fungal Phylum Microsporidia
21
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
21
01:29Bacterial Flora of the Large Intestine
484
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
484
01:23Anatomy of the Intestines
72.2K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.2K