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Updated: Jul 12, 2025

TGF-β-mediated Endothelial to Mesenchymal Transition EndMT and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing
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通过DNMT3A介导的SOX17表观遗传沉默有助于内皮细胞迁移和纤维细胞激活在伤口愈合过程中

Xiaoping Yu1, Xiaoting Ma2, Junli Zhou1

  • 1The Department of Burn, Gansu Provincial Hospital, Lanzhou, China.

PloS one
|October 19, 2023
PubMed
概括

DNA甲基转移酶3α (DNMT3A) 降低了SRY盒转录因子17 (SOX17) 的调节,通过增强内皮细胞迁移和纤维细胞激活来促进伤口愈合. 这一发现为慢性伤口愈合提供了新的治疗策略.

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