维生素D状态与前十字带重建后的骨肌损失有关
Yuan Wen1,2,3, Christine M Latham1, Angelique N Moore1
1Center for Muscle Biology, College of Health Sciences.
JCI insight
|October 19, 2023
概括
在前十字带重建 (ACLR) 之前维持足够的维生素D (25氧维生素D) 水平可能有助于保持四头肌肉质量. 较低的维生素D状态与ACLR后更大的肌肉纤维损失相关.
科学领域:
- 整形外科 整形外科 整形外科
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 足够的25-氧维生素D [25(OH) D] (≥30 ng/mL) 与降低受伤风险和增强强度有关.
- 维生素D状况对前十字带重建 (ACLR) 结果的影响尚不清楚.
- 调查维生素D在骨肌肉和骨恢复后ACLR的作用至关重要.
研究的目的:
- 在ACLR之后检查维生素D信号通路的反应.
- 为了确定手术前维生素D状态和ACLR后肌肉/骨结果之间的关系.
- 为了确定参与ACLR恢复的维生素D受体 (VDR) 目标基因.
主要方法:
- 在21名ACLR患者中分析了血液样本,巨大的横向肌肉活检,骨密度扫描和异动力学强度测试.
- 活检用于横截面积 (CSA),西部斑点,RNA测序和VDR ChIP测序.
- 测量是在基线,ACLR后1周,4个月和6个月进行的.
主要成果:
- ACLR诱导肌肉维生素D信号的变化,包括减少生物活性维生素D和增加VDR表达.
- 与具有足够水平的患者相比,患有较低25OH) D水平 (<30 ng/mL) 的患者在ACLR后经历了显著更大的四头肌纤维CSA损失.
- 综合的omics数据确定了与能量代谢和肌肉恢复相关的潜在VDR基因.
结论:
- 术前维生素D的充足量可能对在ACLR后保持骨肌肉质量很重要.
- 在ACLR之前优化维生素D水平可能是改善恢复的策略.
- 维生素D状态影响骨肌肉恢复途径ACLR后.
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