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在儿科外体膜氧化治疗中,维护小瓶抗素III协议的结果

McKenzie R Young¹, Sara W Hovey¹, Taemyn K Hollis²

¹From the Department of Pharmacy, Rush University Medical Center, Chicago, Illinois.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

|October 19, 2023

概括

在儿科外体膜氧化 (ECMO) 中,用于替代抗血素III (AT3) 的小瓶节约方案显著降低了成本,而不会影响安全性或疗效. 这种方法为AT3管理提供了具有成本效益的替代方案.

科学领域:

儿科重症监护医学儿科重症监护医学
药物经济学药物经济学
心肺支提供心肺支

背景情况:

外源抗素III (AT3) 在儿科外体膜氧化 (ECMO) 中用于增强肝素反应.
目前的AT3管理和剂量协议在ECMO中心之间有很大的差异.

研究的目的:

在儿科ECMO患者中比较两种不同的AT3替代方案的疗效,安全性和成本效益.
为了降低成本,评估从基于重量的协议 (WBP) 过渡到省瓶协议 (VSP).

主要方法:

从2013年12月到2021年8月,对47名儿科ECMO患者进行了回顾性分析.
基于体重的协议 (WBP) 和省瓶协议 (VSP) 之间的结果比较.
评估肝素监测水平,血液产品的使用,不良事件和与电路有关的问题.

主要成果:

在WBP (56.5%) 和VSP (60.7%) 之间的目标范围内的肝素监测水平百分比没有显著差异.
血液制品的使用率,出血/血栓事件,机械故障和电路变化也相似.
VSP导致AT3处置和使用单位显著减少,使中位成本从15,610.62美元降至7,765.56美元.

结论:

维护小瓶的AT3替换协议是儿科ECMO的成本效益高的策略.
该VSP证明了与WBP相比的有效性和安全性.
实施VSP可以在ECMO中心节省大量的资金.

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