美国新墨西哥州的工业空气污染和低出生体重
Xi Gong1, Yanhong Huang1, Jenny Duong2
1Department of Geography & Environmental Studies, UNM Center for the Advancement of Spatial Informatics Research and Education (ASPIRE), University of New Mexico, Albuquerque, NM, 87131, USA.
Journal of environmental management
|October 19, 2023
概括
孕妇在怀孕期间暴露在和烯等特定空气污染物中,与低出生体重 (LBW) 的风险增加有关. 这项研究确定了新墨西哥州与LBW相关的五种工业化学品,突出了严重的公共卫生问题.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 新墨西哥州的低出生体重 (LBW) 率持续高,超过全国平均水平.
- 母亲暴露于工业空气污染是LBW的潜在环境风险因素.
研究的目的:
- 调查母亲在住宅中暴露于工业空气污染物和LBW风险之间的关联.
- 确定在新墨西哥州导致LBW的特定化学物质.
主要方法:
- 利用了22375个LBW病例和233340个对照的大量数据集.
- 使用排放加权近距离模型 (EWPM) 来评估母亲对14种工业化学品的暴露.
- 进行了二进制后勤回归分析,对许多混因素进行了调整,并应用了错误发现率校正.
主要成果:
- 母亲暴露于1,2,4-三甲基,,,乙基和 styrene 显示出与LBW有显著的积极关联.
- 对于这五种化学物质,LBW的调整赔率比率在1.10至1.13之间.
- 显著的线性趋势证实了暴露于这些化学物质和LBW风险之间的剂量反应关系.
结论:
- 住宅暴露于特定的工业空气污染物是新墨西哥州LBW的重要风险因素.
- 1,2,4-三甲基被确定为LBW的新风险因素.
- 需要进一步的流行病学,生物学和毒理学研究来证实这些发现.
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