早期肠道营养干预促进了创伤性脑内出血患者的多重功能恢复:一项前性随机对照研究
Jingjing Wang1, Ke Yu1, Yuping Zeng1
1Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, China.
Clinical neurology and neurosurgery
|October 19, 2023
概括
早期的肠道营养显著改善了创伤性脑内出血患者的功能恢复. 这种干预可以增强神经功能,改善肠道健康,降低死亡风险.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 关键护理医学 关键护理医学
背景情况:
- 创伤性脑内出血 (TICH) 在患者康复方面存在重大挑战.
- 优化营养支持对于管理TICH患者和改善结果至关重要.
研究的目的:
- 研究早期肠道营养干预对TICH患者功能恢复的影响.
- 为了比较早期与延迟肠道营养对生理和神经学的结果的影响.
主要方法:
- 一项前性随机对照研究,涉及152名TICH患者.
- 患者被分为早期肠道营养组 (≤48小时) 和延迟营养组 (>48小时).
- 评估的结果包括格拉斯哥昏迷量表 (GCS),格拉斯哥结果量表 (GOS),修改的兰金量表 (mRS),荷尔蒙水平,肠道微生物群和生存率.
主要成果:
- 与延迟组相比,早期营养组的GCS和GOS得分显著更高,mRS得分更低.
- 早期干预导致上腺皮质激素 (ACTH) 和皮质醇 (Cor) 的水平增加,以及肠道细菌 (Bifidobacteria,Enterococcus,Escherichia coli) 的更显著变化.
- 卡普兰-梅尔生存分析显示,在接受早期肠道营养的患者中,生存曲线的实质性益处很大.
结论:
- 早期的肠道营养可以促进TICH患者的神经功能恢复.
- 这种干预改善了肠道菌群,营养状况,并减少了压力引起的损伤因素.
- 早期肠道营养与TICH患者的较低死亡风险有关.
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