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在75岁以上的中国人中,端粒的长度

Suey S Y Yeung¹, Suk Ling Ma², Xingyan Wang^3,4,5,6

¹Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong, China.

|October 19, 2023

概括

75岁以上的中国成年人中的端粒长度 (TL) 在男性中比女性更短. 与之前的发现不同,TL与老年人群中与年龄相关的疾病,虚弱或肉症无关.

科学领域:

老年学是指老年学的学科.
分子生物学分子生物学
公共卫生公共卫生

背景情况:

端粒长度 (TL) 是一个已知的衰老生物标志物,通常与患病率相反.
之前的研究主要集中在年轻人群中,老年人之间的关联不太清楚.
有限的研究已经研究了中国老年人的TL及其决定因素.

研究的目的:

为了检查75岁及以上的中国人的端粒长度 (TL).
为了确定与TL相关的因素在这个人口.
确定TL与多病症,与年龄相关的疾病,虚弱和肉症之间的关系.

主要方法:

555名中国参与者 (平均年龄为83.6岁) 的横截面研究,来自骨质疏松症先生和夫人队列.
使用分子逆向探针定量PCR试验 (T/S比) 测量TL.
使用调整的二进制物流回归来检查的关联.

主要成果:

与女性 (1.07) 相比,男性表现出较短的TL (平均T/S比0.97) (p < 0.001).
较低的教育水平与较长的TL相关 (p = 0.016),而目前的吸烟与较短的TL相关 (p = 0.007).
没有发现TL与多病症,特定与年龄相关的疾病,虚弱或肉症之间有显著的关联.

结论:

在75岁以上的中国成年人中,男性的端粒长度 (TL) 比女性更短.
在这个队列中,TL与与年龄相关的疾病,虚弱或肉症没有显著的关联.
这些发现表明,TL可能不能作为老年人衰老的可靠生物标志物.

关键词:

衰老的衰老衰老的衰老生物标志物生物标志物华人中文华人中文是什么意思疾病发病率疾病发病率泰洛米尔 (Telomere) 是一种电离体.

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