对平民创伤后应激障碍的托皮拉单疗法:一项受控试点研究
Varun Monga1,2, Frederick Petty3,4, Kalpana Padala5,6
1Banner Thunderbird Medical Center, Glendale, Arizona.
The primary care companion for CNS disorders
|October 19, 2023
概括
托皮拉在平民中显示出治疗创伤后应激障碍 (PTSD) 的潜力,趋势表明与安慰剂相比有所改善. 然而,这些差异没有达到统计学意义,表明需要进一步研究.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 创伤后应激障碍 (PTSD) 是一种使人虚弱的疾病,需要有效的治疗.
- 托皮拉是一种抗药物,具有潜在的神经精神病学应用.
研究的目的:
- 评估托皮拉玛特在被诊断患有PTSD的平民成年人中的疗效,安全性和耐受性.
- 为了在12周的治疗期内比较托皮拉马特与安慰剂的影响.
主要方法:
- 一项为期12周的,双盲,随机,安慰剂控制的研究,涉及72名患有PTSD的门诊患者.
- 通过临床医生管理的PTSD尺度 (CAPS) 评分评估有效性;通过不良事件和临床评估监测安全性.
主要成果:
- 托皮拉与安慰剂 (29.5%) 相比,CAPS得分的百分比下降更大 (39.5%),尽管在统计学上不显著 (P=.31).
- 趋势有利于在CAPS子级分数中对topiramate进行重新体验,避免/麻木和过度兴奋症状的评分,但缺乏统计学意义.
- 与安慰剂相比,托皮拉马特组中较少的患者经历了与AE相关的中止 (18%vs26%).
结论:
- 在这个平民队伍中,托皮拉与安慰剂相比,显示出改善PTSD症状的趋势.
- 虽然一般耐受性很好,但观察到的差异没有达到统计学意义.
- 建议进行进一步的足够强大的研究,以确认托皮拉玛在PTSD治疗中的有效性.
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