大脑功能连接体的拓效率被破坏 de novo 帕金森病与抑郁症
Hui Wang1, Xiaoyan Zhan2, Jianxia Xu3
1Department of Neurology, Lianyungang Hospital of Traditional Chinese Medicine, Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine, Lianyungang, China.
The European journal of neuroscience
|October 19, 2023
概括
帕金森病 (PD) 中的抑郁症与大脑网络拓学的改变有关. 新诊断的患者表现出 temporal-occipital 区域的干扰,这表明PD 抑郁症的潜在网络生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 抑郁症是帕金森病 (PD) 的一个常见的非运动症状.
- 有证据表明,与PD相关的抑郁症源于神经网络的破坏,而不仅仅是区域性脑损伤.
- 了解这些网络变化对于识别生物标志物和改善治疗至关重要.
研究的目的:
- 在帕金森病 (DPD) 的新型抑郁症中调查大脑功能网络的拓变化.
- 探索神经网络是PD患者抑郁症状的基础.
- 确定潜在的网络生物标志物,用于早期诊断DPD.
主要方法:
- 使用了静止状态功能磁共振成像 (rs-fMRI) 数据.
- 应用图形理论和基于网络的统计方法来分析大脑网络拓.
- 招募了三组:20个DPD,37个非抑郁PD和41个健康对照 (HC).
主要成果:
- DPD患者在左上旋中表现出节点效率降低.
- 观察到枢纽分布的变化,在叶皮层的枢纽减少,在边缘皮层-基底腺节电路中的枢纽增加.
- 一个特定的子网络显示,与HC相比,DPD的连接性明显较低,涉及视觉,体运动,背部注意力和默认模式网络.
结论:
- 在叶皮层的区域拓学障碍是DPD的神经机制的关键.
- 改变的大脑网络连接模式可能成为新诊断的DPD患者的潜在生物标志物.
- 这些发现强调了网络层面分析在理解和诊断帕金森病中抑郁症方面的重要性.
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