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异性瘤和免疫细胞重编程的基础免疫疗法反应和免疫相关的不良事件在肺状细胞癌

Minjiang Chen¹, Pengfei Ma², Yongchang Zhang³

¹Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Journal for immunotherapy of cancer

|October 19, 2023

概括

免疫检查点抑制剂 (ICI) 对肺状细胞癌 (LUSC) 是有前途的,但可能会发生与免疫相关的不良事件 (irAEs). 这项研究揭示了特定的免疫细胞变化和与LUSC患者的治疗反应和irAEs相关的TNF信号改变.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
基因组学就是基因组学.

背景情况:

肺状细胞癌 (LUSC) 的治疗选择有限.
免疫检查点抑制剂 (ICI) 提供有效性,但可能导致与免疫相关的不良事件 (irAEs).
了解免疫反应和irAEs对于优化LUSC的ICI治疗至关重要.

研究的目的:

描述与ICI治疗反应和LUSC中的irAEs相关的免疫特征.
阐明TNF信号传导在抗瘤免疫和irAE发展中的作用.

主要方法:

在ICI治疗前和期间,瘤活检的单细胞RNA测序 (scRNA-seq).
大量RNA测序匹配的瘤和受影响的器官.
在独立的患者队列中分析循环TNF蛋白水平.

主要成果:

显著的巨细胞,T细胞和瘤细胞子集群与ICI反应和irAEs有关.
TNF信号通路在抗瘤免疫和irAEs中发挥了不同的作用.
在irAE患者中观察到循环TNF蛋白水平的增加,但不是ICI反应者.

结论:

特定的免疫细胞重编程和TNF信号传递动态与LUSC中的ICI反应和irAEs有关.
在LUSC环境中,TNF表达对irAE发育具有重要意义.
这些发现可能有助于最大限度地提高ICI的益处,并在LUSC患者中管理irAEs.

关键词:

免疫检查点抑制剂免疫检查点抑制剂肺部新生体肺部新生体瘤微环境瘤微环境

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