多基因倾向,睡眠时间和抑郁症:来自前性基于人口的队列队列的证据
Odessa S Hamilton1, Andrew Steptoe2, Olesya Ajnakina2,3
1Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK. odessa.hamilton.19@ucl.ac.uk.
Translational psychiatry
|October 19, 2023
概括
对睡眠短暂的多基因倾向增加了老年人抑郁症的风险. 然而,抑郁症的遗传风险并没有预测睡眠时间的变化,这表明这些关联存在不同的潜在机制.
科学领域:
- 行为科学 行为科学
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 睡眠持续时间不足和抑郁症经常同时发生,短睡眠和长睡眠通常被认为是抑郁症的症状.
- 新出现的证据表明,低于最佳的睡眠可能是抑郁症的前兆,但这种关系的方向性仍然不清楚.
研究的目的:
- 为了研究睡眠持续时间 (短睡眠和长睡眠) 和老年人抑郁症发作之间的潜在方向性.
- 利用多基因分数 (PGS) 来评估睡眠持续时间和抑郁症的遗传倾向.
主要方法:
- 分析了来自英国长度老龄化研究 (ELSA) 的50岁以上的参与者.
- 睡眠时间,短睡眠和长睡眠的多基因分数 (PGS) 来自英国生物银行数据.
- 睡眠时间 (短,最佳,长) 和亚临床抑郁症在基线和8年随访期间被评估.
主要成果:
- 短时间睡眠的PGS增加1个标准偏差与14%更高的抑郁症发病率显著相关 (p=0.008).
- 总体睡眠时间和长时间睡眠的PGS与抑郁症发作没有显著联系.
- 抑郁症的PGS与随访期间的整体睡眠时间,短睡眠或长睡眠没有关联.
结论:
- 对睡眠短暂的多基因倾向有望与老年人抑郁症发作有关.
- 抑郁症PGS和随后的睡眠时间之间缺乏关联,这表明这些关系背后存在着不同的生物机制.
- 这些发现凸显了睡眠不足作为老年人群中抑郁症潜在的前兆指标.
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