鱼的低突变率与鱼进化的缓慢速度一致
Ashley T Sendell-Price1,2, Frank J Tulenko3, Mats Pettersson1
1Department of Medical Biochemistry and Microbiology, Uppsala University, SE75123, Uppsala, Sweden.
Nature communications
|October 19, 2023
概括
双肩的核突变率非常低,估计每一代每基对为7x10-10 . 这一发现支持鱼作为一种缓慢进化的血统,可能会影响它们恢复遗传多样性的能力.
科学领域:
- 海洋生物学 海洋生物学
- 进化遗传学 进化遗传学
- 基因组学就是基因组学.
背景情况:
- 鱼是重要的海洋捕食者和缓慢进化的血统,可能与低癌症率有关.
- 较低的核突变率可以解释鱼中观察到的这些特征.
- 缺乏对鱼突变率的直接估计.
研究的目的:
- 为了直接估计带鱼 (Hemiscyllium ocellatum) 的核突变率.
- 为了研究基底脊椎动物低突变率的进化影响.
主要方法:
- 生成一个高质量的双肩鱼参考基因组.
- 父母-后代三组 (九个家族) 的全基因组再测序.
- 检测和严格过新的突变.
主要成果:
- 据估计,鱼的核突变率是每基数对每代7×10−10.
- 这是任何脊椎动物中报告的最低突变率之一.
- 低速率表明一个缓慢演变的血统.
结论:
- 大鱼的核突变率非常低.
- 这种低速率支持了鱼是缓慢进化的血统的假设.
- 低突变率可能会阻碍在人口瓶后恢复遗传多样性.
相关概念视频
Gene Evolution - Fast or Slow?
7.1K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
7.1K
Speciation Rates
21.2K
Overview
21.2K
Convergent Evolution
27.8K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
27.8K
The Evidence for Evolution
42.8K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
42.8K
Multi-species Conserved Sequences
3.9K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
3.9K
Gene Duplication and Divergence
6.1K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
6.1K


