对患有严重COVID-19的吸烟者的病毒和免疫学评估
Joseph Vecchio1, James Regan2, Yuting Jiang1
1Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA, USA.
Scientific reports
|October 19, 2023
概括
吸烟似乎不会影响对COVID-19疫苗或感染的抗体反应. 高病毒载量,而不是抗体水平,在吸烟的严重COVID-19患者中预测死亡率.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 众所周知,吸烟会损害B细胞功能和免疫球蛋白的产生.
- 吸烟引起的免疫功能障碍对严重的COVID-19风险的影响尚不清楚.
- 了解严重COVID-19吸烟者的免疫反应对于风险分层至关重要.
研究的目的:
- 调查吸烟相关的免疫功能障碍是否有助于严重的COVID-19结果.
- 为了比较抗体反应 (结合和中和) 在严重的COVID-19患者和没有吸烟史.
- 为了确定与吸烟者中严重的COVID-19死亡率相关的因素.
主要方法:
- 评估了IgM,IgA和IgG抗体结合SARS-CoV-2尖端和受体结合域抗原.
- 量化SARS-CoV-2伪病毒中和标位. 数量化SARS-CoV-2伪病毒中和标位.
- 分析了27名患有严重COVID-19的患者的数据,比较吸烟者和非吸烟者.
主要成果:
- 在吸烟者和非吸烟者之间,在抗体结合或中和标位上没有发现显著差异.
- 高血病毒载量显著与死亡风险增加有关.
- 在这个队列中,抗体标位与死亡风险没有相关性.
结论:
- 幽默性免疫功能障碍似乎不是吸烟者严重COVID-19的主要驱动因素.
- 病毒载量是死亡的一个更重要的预测因素,而不是在严重的COVID-19中抗体反应.
- 目前的研究结果表明,吸烟对适应性免疫的影响可能不会显著改变与抗体功能相关的COVID-19严重性结果.
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