成年期代谢参数的长期平均值与晚年心脏结构和功能之间的关联
Yuzhong Wu1,2, Chen Chen1,2, Fang-Fei Wei1,2
1Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, P R China.
概括
长期的体重指数 (BMI) 和血压 (BP) 影响心脏的结构和功能. 更高的高密度脂蛋白胆固醇 (HDL-c) 与更好的心脏缩功能有关.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 心血管健康受到长期生活方式因素的影响.
- 了解代谢参数对心脏结构和功能的影响,对于预防性心脏病学至关重要.
研究的目的:
- 评估体质指数 (BMI),血压 (BP),血脂和禁食血糖 (FBG) 对心脏结构和功能的长期影响.
- 确定这些参数持续水平与晚年心脏测量之间的关联.
主要方法:
- 分析了来自弗雷明汉心脏研究的数据,包括没有心力衰竭的成年参与者.
- 在30-36年内对7个参数 (BMI,BP,脂质,FBG) 的纵向评估.
- 用于将长期平均值与心脏结构 (LAID,LVMi,LVID) 和功能 (LVEF,GLS,E/é) 相关联的线性回归模型.
主要成果:
- 增加的BMI与更大的心室尺寸 (LAID,LVID),增加的质量 (LVMi) 和扩张功能受损 (E/é) 相相关.
- 静脉血压与LVMi,LVEF和E/é的增加有关,而腹静脉血压与LVMi,LVEF和E/é的反向相关.
- 较高的高密度脂蛋白胆固醇 (HDL-c) 与较小的LVID和改善的缩功能 (LVEF,GLS) 有关.
结论:
- 长期的BMI显著影响心脏腔的大小和质量.
- 缩和腹缩血压对左心室质量和功能产生不同的影响.
- 升高的HDL-c与更好的心脏缩性表现有关,突出其保护作用.
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