鼠前方定位场动态编码在风险下经济决策的价值
Chaofei Bao1,2,3,4, Xiaoyue Zhu1,2,3, Joshua Mōller-Mara1,2,3
1NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, China.
Nature neuroscience
|October 19, 2023
概括
研究人员使经济选择的老鼠的前额定向场 (FOF) 和后额叶皮层 (PPC) 沉默. 沉默FOF降低了寻求风险的行为,揭示了其在代表彩票价值的决定性风险下发挥的关键作用.
科学领域:
- 神经科学是一个神经科学.
- 决策科学 决策科学 决策科学
- 行为经济学是一种行为经济学.
背景情况:
- 众所周知,额叶和顶叶皮层参与经济决策.
- 然而,它们在处理风险和价值方面的特定因果作用仍然在很大程度上未经测试.
研究的目的:
- 调查前额定向场 (FOF) 和后额叶皮层 (PPC) 在经济决策中的因果作用.
- 阐明在评估不确定的奖励基础上的神经机制.
主要方法:
- 在执行风险彩票和确定注之间的选择任务的老鼠中,FOF和PPC的非激活.
- 使用混合代理模型评估实用功能的变化行为分析.
- 电生理学记录用于分析决策过程中FOF中的神经活动.
主要成果:
- 关闭后顶层皮质 (PPC) 对选择的影响极小且短暂.
- 沉默前方定向场 (FOF) 显著减少了彩票的选择,表明风险偏好发生了变化.
- FOF无活化导致大鼠实用功能的曲率发生变化,这表明风险厌恶的变化.
- 发现FOF中的神经活动在逐个试验的基础上编码了彩票的价值.
结论:
- 额面导向场 (FOF) 在风险下的经济决策中起着关键的因果作用.
- 该FOF对于动态表示和比较不确定的选项 (彩票) 与稳定的选项 (确定注) 的值至关重要.
- 这些发现确定FOF是大脑中基于价值的选择计算的关键神经基质.
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