在ABCB1的遗传多态性与阿托瓦斯塔丁诱导的肌肉副作用的风险增加相关:一个横截面研究
Ninoslava Lalatović1, Maša Ždralević2, Tanja Antunović3
1Faculty of Medicine, University of Montenegro, Kruševac bb, 81000, Podgorica, Montenegro. nina.lalatovic32@gmail.com.
ABCB1基因的遗传变异增加了与他类药物相关的肌肉症状 (SAMS) 的风险,这是他类药物不耐受的常见原因. ABCB1基因定型可能有助于识别患有SAMS风险较高的患者.
科学领域:
- 药物基因组学 药物基因组学
- 心血管药理学心血管药理学
背景情况:
- 类他类药物相关的肌肉症状 (SAMS) 是他类药物不耐受的主要原因.
- 遗传因素与SAMS有关,但关于ABCB1基因多态性的发现仍然存在争议.
研究的目的:
- 研究特定的ABCB1基因多态 (1236C>T,2677G>T/A,3435C>T) 与患SAMS的风险之间的关联.
- 评估非遗传变量对SAMS发展的影响.
主要方法:
- 一项涉及SAMS患者和没有SAMS患者使用阿托瓦斯塔丁的横截面研究.
- 对ABCB1多态 (1236C>T,2677G>T/A,3435C>T) 的基因造型.
- 统计分析以确定基因型,双型,非遗传因素和SAMS风险之间的关联.
主要成果:
- 在1236C>T,2677G>T/A和3435C>T多态的TT基因型患者中,SAMS的风险显著增加 (ORs从3.547到5.897,p<0.05).
- 这种TTT/TTT双型与SAMS风险增加密切相关 (OR 9.234,p=0.0028).
- 对心血管疾病的家族病史被确定为SAMS的额外危险因素.
结论:
- 特定的ABCB1基因多态性 (1236C>T,2677G>T/A,3435C>T) 与与他类药物相关的肌肉症状的风险增加有关.
- ABCB1基因型定型为早期识别SAMS高风险患者提供了潜在的工具,有助于临床管理.
- 心血管疾病的家族病史是SAMS的相关非遗传风险因素.
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