基于混合非线性模型和多变量方法的泽布肉牛早期性识别策略
Johnny Iglesias Mendes Araujo1, Paulo Luiz Souza Carneiro2, Leonardo Siqueira Glória3,4
1State University of Southwestern Bahia, Itapetinga, BA, 45.000-700, Brazil. johnny-iglesias@hotmail.com.
Tropical animal health and production
|October 19, 2023
概括
布罗迪模型最好地描述了泽布 (Zebu) 牛的生长曲线,确定了古泽拉特 (Guzerat) 和塔巴普阿 (Tabapuã) 品种更为早熟. 这有助于养殖者选择牛,以提高牧场系统的经济收益.
科学领域:
- 动物科学动物科学
- 量化遗传学 量化遗传学
- 农业经济学 农业经济学
背景情况:
- 模拟牲畜生长对于优化牧场系统的管理和经济回报至关重要.
- 混合非线性模型通过结合随机效应,提高了估计生长曲线的准确性.
- 了解特定品种的生长模式对于有效的育种和养策略至关重要.
研究的目的:
- 确定最适合的混合非线性模型来描述Zebu牛的生长曲线.
- 通过使用多变量分析,评估泽布牛 (Guzerat,Nellore,Tabapuã,Polled Nellore) 品种的生长多样性.
- 为养殖者和生产者提供见解,以提高基于牧场的系统的经济收益.
主要方法:
- 五种混合非线性模型 (Richards,Brody,Gompertz,Logistic,Von Bertalanffy) 的增长曲线适配的比较.
- 基于不同年龄段的非对称重量 (A),成熟率 (K) 和绝对生长率 (AGR) 的等级集群多变量分析.
- 利用来自巴西养殖场的311,834头泽布牛 (雄性和雌性) 的体重数据.
主要成果:
- 布罗迪模型,具有品种性别固定和动物随机效应,是最适合模拟泽布牛生长的模型.
- 与Nellore和PolledNellore相比,Guzerat和Tabapuã的雄性表现出更高的早熟性 (K).
- 雌性通常比雄性更为早熟,特别是在Tabapuã和Guzerat品种中. 集群分析根据生长参数分离了品种,确定了早熟 (古泽拉特,塔巴普阿) 和晚熟 (内洛尔,波尔德内洛尔) 组.
结论:
- 布罗迪模型有效地捕捉了泽布牛的增长动态.
- 品种和性别显著影响生长早发性和异常体重,对管理有影响.
- 识别古泽拉特 (Guzerat) 和塔巴普阿 (Tabapuã) 等早熟品种可以指导战略决策,以最大限度地提高牛肉生产系统的利能力.
相关概念视频
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
57
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
57
Pedigree Analysis
84.4K
Overview
84.4K
Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches
141
Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
141
Pharmacokinetic Models: Comparison and Selection Criterion
79
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
79
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
70
Drugs administered through various routes can lead to nonlinear elimination, resulting in complex pharmacokinetic behaviors crucial to understanding efficacious drug dosing.
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
70
Nonlinear Pharmacokinetics: Causes of Nonlinearity
206
Nonlinearity in drug pharmacokinetics is caused by various factors influencing how a drug is absorbed, distributed, metabolized, and excreted. Understanding these nonlinear processes is crucial for predicting drug behavior in the body and optimizing drug dosing regimens.
Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...
Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...
206


