在日本环境和儿童研究中产前金属度和身体异常
Yuichi Nakamura1,2, Sumitaka Kobayashi3, Kazutoshi Cho2
1Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Pediatric research
|October 19, 2023
概括
产前接触可能会略微增加新生儿身体异常的风险. 这项研究发现,,,或暴露与出生缺陷之间没有联系.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 儿科 儿科 儿科
背景情况:
- 产前金属暴露与先天异常之间的联系需要进一步调查.
- 了解出生缺陷的环境风险因素对于公共卫生至关重要.
研究的目的:
- 检查,,,和在母亲血液中的度与婴儿身体异常的发生之间的联系.
- 为了识别可能在怀孕期间构成风险的特定金属.
主要方法:
- 利用了日本环境和儿童研究 (JECS) 中89,887例单独怀孕的数据.
- 采用后勤回归模型来评估母亲血液中的金属含量与身体异常之间的相关性.
- 身体异常包括先天性异常和在出生或一个月大时观察到的轻微缺陷.
主要成果:
- 孕产妇血液中 (Mn) 度显示出与增加身体异常风险的统计学显著关联.
- 度增加1个单位与身体异常的几率比率 (OR) 为1.26 (95% CI:1.08,1.48) 相关.
- 与最低四分位数相比,暴露率最高四分位数的母亲所生婴儿的风险略高 (OR:1.06,95% CI:1.01,1.13) .
结论:
- 怀孕期间母亲血液中含量升高可能与身体异常发生率略有增加有关.
- 在产前暴露于,,或与身体异常之间没有发现显著的关联.
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