与延长达尔巴万辛治疗肩部假肢关节感染相关的耳毒性
Anna Lange1, Ulrica Thunberg2, Bo Söderquist3
1Department of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden. anna.lange@oru.se.
BMC infectious diseases
|October 19, 2023
概括
这项研究报告了一例罕见的听力损失病例,该病例发生在接受为假肢关节感染延长达尔巴万辛治疗的患者身上. 长期使用达尔巴万辛可能会带来耳毒性风险,需要仔细监测.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 达尔巴万辛是一种 lipoglycopeptide 抗生素,已被批准用于皮肤和软组织感染.
- 它的特性使其对骨和关节感染具有吸引力,包括在门诊环境中.
- 非标签的长期使用可能会带来风险.
研究的目的:
- 报告与延长达尔巴万辛治疗相关的耳毒性罕见病例.
- 为了突出使用达尔巴万辛超出已批准的指南的潜在风险.
主要方法:
- 一个55岁的男性患者的病例报告,患有假肢肩关节感染.
- 非标签延长的达尔巴万辛治疗,累计剂量为2500毫克.
- 监测不良影响,特别是听力功能.
主要成果:
- 患者在开始服用达尔巴万辛后发展出双侧神经传感性听力损失.
- 停用抗生素后,听力损失至少持续1年.
- 这代表了与dalbavancin相关的罕见不良事件.
结论:
- 延长达尔巴万辛治疗超过批准剂量需要谨慎.
- 在接受dalbavancin的患者中,对潜在的耳毒性保持警至关重要.
- 这一案例强调了在长期抗生素治疗期间监测听力功能的重要性.
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