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与铁死相关的lncRNAs指导骨髓瘤预后和免疫微环境

Mingyi Yang¹, Yani Su¹, Ke Xu¹

¹Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, 710054, Shaanxi, China.

Journal of orthopaedic surgery and research

|October 19, 2023

概括

这项研究确定了七种与铁亡相关的长非编码RNA (FRLncs),这些RNA会影响骨髓瘤 (OS) 的预后和免疫微环境. 这些FRLncs为OS患者的治疗结果和治疗策略提供了潜在的生物标志物.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
免疫学免疫学免疫学

背景情况:

骨肉瘤 (OS) 的预后和免疫微环境是复杂的,需要新的生物标志物.
与铁亡相关的长非编码RNA (FRLncs) 正在成为各种癌症的关键调节者.

研究的目的:

确定与骨髓瘤 (OS) 的预后和免疫微环境相关的FRLncs.
开发基于FRLncs的OS风险预后模型.
为OS管理中的临床决策提供框架.

主要方法:

从86个OS病例和公共数据集 (GSE19276,GSE16088,GSE33382) 中分析了转录组和临床数据.
通过联合表达分析识别差异表达的铁与相关的基因 (FRGs) 和FRLncs.
使用考克斯回归,生存分析和ssGSEA用于免疫细胞透和功能的风险预后模型的构建和验证.

主要成果:

七个FRLncs被确定为预后标志物:三个高风险 (APTR,AC105914.2,AL139246.5) 和四个低风险 (DSCR8,LOH12CR2,AC025048.2,AC027307.2).
高风险组显示了中性粒细胞,NK细胞,血细胞状树突细胞和瘤透淋巴细胞的下调,以及免疫功能受损.
七个与免疫检查点相关的基因 (CD200R1,HAVCR2,LGALS9,CD27,LAIR1,LAG3,TNFSF4) 与OS预后有关.

结论:

FRLncs显著影响OS预后和免疫微环境,作为潜在的预后生物标志物.
已识别的与免疫检查点相关的基因对于OS预后至关重要.
该研究为了解OS存活提供了基础,并为临床策略提供了信息.

关键词:

铁化是铁化的一种.基因基因基因基因基因豁免权是一种豁免权.这是一个LncRNARNA.骨质肉瘤骨质肉瘤是什么预测预后预后

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