确定空气污染暴露在怀孕前和怀孕期间的关键窗口对出生体重的影响:一项前性队列研究
Jiawen Liao1, Yi Zhang2, Zhenchun Yang3
1Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
Environmental health : a global access science source
|October 19, 2023
概括
在怀孕中期到晚期暴露于二氧化和细颗粒物增加了对妊娠年龄小的分娩的风险. 怀孕前的空气污染暴露对出生结果没有显著影响.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 围产期结果 围产期结果
背景情况:
- 关于空气污染在怀孕前和怀孕期间对出生体重的影响的研究有限.
- 空气污染是全球对母亲和儿童健康日益关注的问题.
研究的目的:
- 调查预孕和怀孕期间暴露于NO2和PM2.5以及出生结果之间的关联.
- 确定怀孕期间暴露的关键窗口,与不良分娩结果相关.
主要方法:
- 分析了在上海 (2016-2018) 的14220名孕妇和新生儿的队列.
- 高分辨率的时空模型估计了NO2和PM2.5的暴露.
- 线性,物流和分布式滞后模型评估了与出生体重,Z分数,SGA和LGA的关联.
主要成果:
- 在第二和第三个三个月中增加的NO2暴露与更高的SGA风险有关.
- 第三季度的PM2.5暴露也与SGA的风险增加有关.
- 对于出生体重,Z-score或LGA没有发现显著的关联;怀孕前的暴露没有影响.
结论:
- 在怀孕中期和晚期暴露于空气污染与不良分娩结果有关,特别是SGA.
- 怀孕22-32周是NO2暴露对SGA的影响的关键窗口.
- 研究结果表明,女性新生儿的相关性更强,需要进一步调查.
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