大麻与神经性厌食症之间的关系:一个范围审查
Chloe I Rogers1, Carly R Pacanowski2
1Department of Health Behavior and Nutrition Sciences, University of Delaware, Newark, Delaware, USA. chloerog@udel.edu.
Journal of eating disorders
|October 20, 2023
概括
神经性厌食症 (AN) 患者表现出内分泌系统 (ECS) 异常,这表明大麻可能有助于重量恢复和症状改善. 建议对个性化剂量进行进一步的研究,以平衡益处和危害.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 神经性厌食症 (AN) 的复发率很高,需要新的治疗策略.
- 大麻素激动剂表现有前途,先前在治疗诸如创伤后应激障碍等并发症方面取得了成功.
- 内分泌大麻素系统 (ECS) 涉及到AN的病理生理学.
研究的目的:
- 在神经性厌食症 (AN) 中对内分泌系统 (ECS) 进行范围审查.
- 探索大麻素治疗在AN中的潜在益处,危害和零效应.
- 为了检查与大麻使用相关的危害,在个人与AN.
主要方法:
- 在PubMed,PsycINFO,Cochrane和Web of Science (2010-2023) 搜索了关于ECS,大麻素治疗或AN大麻使用的研究.
- 包括在标题/摘要中使用"大麻"和"AN"关键词的人类研究;不包括二次性厌食症,非英语,灰色文献,综合数据和仅流行报告.
- 提取了ECS遗传学,大麻素受体的可用性,内分泌大麻素水平,治疗效应 (体重,ED症状,PA,荷尔蒙) 和大麻使用危害的数据.
主要成果:
- 八项研究揭示了AN的ECS异常,包括遗传变异,受体可用性和内分泌卡纳比诺伊德水平.
- 三项研究报告了混合大麻素治疗效果:益处 (体重增加,改善ED症状,降低PA),零效应和危害 (增加PA,降低脂肪激素).
- 四项研究强调了大麻使用的危害,例如对大麻使用障碍的遗传倾向和补偿行为.
结论:
- 有限的证据表明,与AN相关的ECS异常可能使大麻成为恢复体重和相关症状的潜在治疗方法.
- 建议采用个性化剂量策略,以优化大麻素治疗的疗效,同时最大限度地减少副作用.
- 需要进一步的研究来探索大麻素在神经性厌食症的治疗潜力.
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