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[HER2表皮生长因子受体,用于寻找其在乳腺癌中放大作用的测试:原理和局限性]

Imane Eliahiai¹, Mohammed Eljiar¹, Sanae Chaib¹

¹Laboratoire d'anatomie et cytologie pathologique, centre hospitalier universitaire Mohammed VI Tanger-Tétouan-Al Hoceima (TTA), 90000 Tangier, Maroc; Université Abdelmalek-Essaadi, faculté de médecine et de pharmacie de Tangier, Tangier, Maroc.

Bulletin du cancer

|October 20, 2023

概括

检测HER2阳性乳腺癌对于治疗至关重要. 本综述涵盖了影响HER2测试准确性的方法和因素,包括新的HER2-低亚型.

科学领域:

在瘤学瘤学.
病理学病理学病理学
遗传学遗传学是一个

背景情况:

HER2阳性乳腺癌占侵袭性病例的20%,与更高的复发率,大脑转移和较差的存活率有关.
ERBB2基因放大预测了对抗HER2疗法的反应,因此精确的HER2状态确定至关重要.
最近对低HER2亚型的鉴定凸显了HER2测试的不断变化的格局.

研究的目的:

审查目前用于确定乳腺癌中HER2状态的技术.
分析影响HER2测试解释的分析前和内在瘤因素.
为该领域的临床医生和研究人员提供全面的概述.

主要方法:

对HER2状态确定技术的文献综述.
对HER2测试的ASCO/CAP 2018年指南的分析.
对影响免疫组织化学和光的因素的检查 in situ 杂交结果.

主要成果:

免疫组织化学是推的初始测试,在模两可的情况下进行光 in situ 杂交.
分析前的变量 (如固定,储存) 和瘤异质性可以显著影响HER2测试的准确性.
了解这些因素对于可靠的HER2状态评估至关重要.

结论:

准确的HER2状态确定对于指导抗HER2疗法选择至关重要.
需要了解分析前和瘤特异性因素,以避免对HER2结果的误解.
进一步研究低HER2亚型和优化测试方法是有必要的.

关键词:

艾伦的信使 de lHER2 生物检查液体的液体乳腺癌是什么? 乳腺癌是什么乳腺癌是因为乳腺癌.HER2 传递 RNA 的 HER2 传递 RNA 的 HER2 在HER2+的基础上,HER2+在现场进行杂交.免疫组织化学免疫组织化学免疫组织化学在现场混合化.液体活检液体活检抗HER2治疗耐药性的原则抗HER2治疗耐药性的原则

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