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针对D-招募部位的ERK2小分子抑制剂的鉴定和生物化学表征

R M Sammons1, E J Cho1, K N Dalby2

  • 1Targeted Therapeutic Drug Discovery and Development Program, The University of Texas at Austin, Austin, TX, United States.

Methods in enzymology
|October 20, 2023
PubMed
概括

新的小分子通过向D-招募部位 (DRS) 来抑制ERK2,为癌症治疗提供了一种新的策略. 这种方法绕过了与传统ERK通路抑制剂相关的抵抗机制.

关键词:
D-招聘网站 招聘网站停靠站点是对接站点.细胞外信号调节激酶2 (ERK2) 是一种细胞外信号调节激酶.光异质性是一种光异质性.高通量选的高通量选蛋白质蛋白质相互作用小分子抑制剂 小分子抑制剂

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