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标准化阿育吠陀配方的安全性评估 - - Panchvalkala,通过亚急性毒性研究
Shama Aphale1, Kavita Shinde2, Manjiri Karandikar3
1Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Katraj-Dhankawadi, Pune-Satara Road, Katraj, Pune, 411043, Maharashtra, India; Department of Pharmaceutical Biotechnology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed to be University, Erandwane, Pune, 411038, India.
Journal of ethnopharmacology
|October 20, 2023
概括
在小鼠28天的亚急性毒性研究中,Panchvalkala水性提取物 (PVaq) 没有显示任何不良影响. 这种阿育吠陀药物在男性和女性瑞士白色老鼠口服时是安全的.
科学领域:
- 艾尔韦达医学是一种医药.
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 潘奇瓦卡拉是一种传统的阿育吠陀配方,用于妇科问题.
- 最近的研究表明,潘奇瓦卡拉水性提取物 (PVaq) 的抗癌特性.
- 这项研究调查了PVaq.的安全性.
研究的目的:
- 为了评估Panchvalkala水性提取物 (PVaq) 的亚急性毒性.
- 评估PVaq在口服后在瑞士白色小鼠中的安全性.
主要方法:
- 瑞士白色老鼠 (n=5/sex/group) 每天服用PVaq (250,500或1000毫克/公斤) 的口服剂量,持续28天.
- 监测了临床观察,体重,食物/水摄入量,尿液,血液学和生物化学参数.
- 在治疗后,对重要器官进行了组织病理学检查.
主要成果:
- 服用PVaq并没有导致体重,食物或饮用水量的显著变化.
- 血液学,生化学或尿液参数没有显著变化.
- 组织病理学分析显示,与对照小鼠相比,治疗小鼠的重要器官没有异常.
结论:
- 在亚急性毒性研究中,口服Panchvalkala水性提取物 (PVaq) 是安全的.
- PVaq在雄性和雌性瑞士白色老鼠中没有显著的毒性影响.
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