草甘暴露与多种不良结果和潜在调解者的关联
Wenxiang Li1, Daizai Lei2, Guangyi Huang2
1Nanjing Medical University, Nanjing, China.
Chemosphere
|October 20, 2023
概括
对除草剂草甘 (GLY) 的暴露与2型糖尿病 (T2DM) 的风险增加有关. 这种关联在一定程度上是由成年人中降低的高密度脂蛋白胆固醇 (HDL) 水平介导的.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 草甘 (GLY) 是一种普遍存在的除草剂,具有潜在的公共卫生影响.
- 目前关于GLY对健康的影响的流行病学证据有限.
- 人们对GLY与慢性疾病的关联存在担忧.
研究的目的:
- 调查草甘暴露与多种健康结果之间的关联.
- 检查尿液GLY度与2型糖尿病 (T2DM),高血压,心血管疾病 (CVD),肥胖和其他疾病之间的联系.
- 在显著的关联中识别潜在的调解者和剂量反应关系.
主要方法:
- 利用了NHANES (2013-2016) 的数据,包括尿液GLY水平和9个健康结果.
- 采用反向尺度的考克斯回归和物流回归来估计关联.
- 进行中介分析和受限立方脊柱 (RCS) 回归,以探索机制和剂量反应关系.
主要成果:
- 尿液GLY度较高与T2DM,高血压,心血管疾病和肥胖症的可能性增加有关.
- 草甘暴露与增加T2DM风险显著相关 (aHR=1.22,aOR=1.30).
- 血清高密度脂蛋白胆固醇 (HDL) 被确定为调解剂 (7.14%的影响),GLY暴露与增加T2DM风险和降低HDL水平有关.
结论:
- 草甘暴露与一般成年人群中2型糖尿病的风险增加有关.
- 血清HDL水平可能会调解草甘暴露和T2DM之间的关系.
- 需要进一步的研究来阐明与草甘暴露相关的健康影响的全部范围.
相关概念视频
01:36Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
01:25Mutagenicity and Carcinogenicity
1.3K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.3K
01:26Toxic Reactions: Overview
991
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
991
01:25Strategies for Assessing and Addressing Confounding
104
Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
104
01:28Global Regulatory Systems
29
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
29
01:19Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K