转换为口服抗生素在格拉姆阴性细菌症:一个随机的,开放的标签,临床试验
Ali S Omrani1, Sulieman H Abujarir2, Fatma Ben Abid3
1Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar; Division of Infectious Diseases, Department of Medicine, Hamad Medical Corporation, Doha, Qatar; Qatar University College of Medicine, Doha, Qatar.
概括
在初始静脉注射治疗肠杆菌性细菌症后,切换为口服抗生素与继续静脉注射治疗一样有效. 这种方法为患者实现临床稳定提供了安全和可行的替代方案.
科学领域:
- 传染性疾病 传染性疾病
- 临床药理学 临床药理学
- 抗微生物药物管理委员会
背景情况:
- 肠杆菌性细菌病需要有效的治疗,通常是通过静脉注射 (IV) 抗微生物药物开始的.
- 过渡到口服治疗可以改善患者的便利性,并降低医疗保健成本.
- 评估口服切换疗法的安全性和有效性对于优化抗菌素使用至关重要.
研究的目的:
- 评估与继续IV治疗相比,切换到口服抗菌药物治疗的非劣势在患有肠杆菌性细菌病的患者中.
- 评估治疗失败率,不良事件和两种治疗策略的安全性概况.
主要方法:
- 一个多中心的,开放的,随机的试验,涉及患有易受肠杆菌细菌病的成人.
- 患者在随机化之前接受了3-5天的IV治疗,以继续IV或切换到口服药物.
- 治疗失败被定义为死亡,额外的抗菌药物需求,复发或在90天内重新入院.
主要成果:
- 治疗失败发生在25.6%的IV组和21.7%的口服转换组 (风险差异 -3.7%,95%CI -16.6%至9.2%).
- 发现口服切换策略与持续的静脉注射治疗相比并非劣.
- 两组之间,不良事件和停止治疗的发生率是可比的.
结论:
- 口服切换疗法是一种安全有效的替代方案,用于临床稳定患者的肠杆菌菌性细菌病的持续静脉治疗.
- 该策略通过可能缩短静脉注射的持续时间来支持抗菌药物管理.
- 这些发现支持实施口服切换协议来控制肠杆菌菌血症.
相关概念视频
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
15
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
15
00:57Antibiotic Selection
54.5K
Overview
54.5K
01:26Tonsillitis II: Management
120
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
120
01:27Combined Effects of Drugs: Synergism
4.0K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
4.0K
01:30Acute Pharyngitis
748
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
748
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
420
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
420