Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

X-ray Crystallography

X-ray Crystallography

The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Dual responsive enzyme mimicking activity of AgX (X=Cl, Br, I) nanoparticles and its application for cancer cell detection.

ACS applied materials & interfaces·2014

Same author

Naphthoquinone-directed C-H annulation and C(sp³)-H bond cleavage: one-pot synthesis of tetracyclic naphthoxazoles.

The Journal of organic chemistry·2014

Same author

Pulmonary toxicity in mice following exposure to cerium chloride.

Biological trace element research·2014

Same author

Role of surgery in the treatment of patients with high-risk neuroblastoma who have a poor response to induction chemotherapy.

Journal of pediatric surgery·2014

Same author

Glutathione-S-transferase polymorphisms (GSTM1, GSTT1 and GSTP1) and acute leukemia risk in Asians: a meta-analysis.

Asian Pacific journal of cancer prevention : APJCP·2014

Same author

Influence of casting solvent on phenyl ordering at the surface of spin cast polymer thin films.

Journal of colloid and interface science·2014

Search research articles

相关实验视频

Updated: Jul 12, 2025

$Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography$

Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography

Published on: April 24, 2018

弱监督学习用于序列秒晶体学中的模式分类.

Jianan Xie, Ji Liu, Chi Zhang

|October 20, 2023

概括

弱监督学习显著减少了对标记数据的需求,在X射线衍射模式的分类. 这一进步有助于从连续的秒结晶学实验中处理大数据集.

科学领域:

结构生物学结构生物学
生物物理学的生物物理.
数据科学数据科学数据科学

背景情况:

在X射线自由电子激光器 (XFELs) 上的连续秒结晶学 (SFX) 可实现高分辨率的晶体结构确定.
处理来自SFX实验的大量衍射图案是一个重大的数据挑战.

研究的目的:

研究机器学习的应用,特别是弱监督的算法,用于SFX中分类衍射模式.
为了减少对训练模式分类模型的大型标记数据集的依赖.

主要方法:

利用弱监督学习算法来对衍射模式进行分类.
在准确性和数据要求方面,比较了弱监管方法与完全监管方法的性能.

主要成果:

弱监管方法的准确性与完全监管方法的准确性相当.
证明了有效训练所需的标记衍射模式的数量显著减少.

结论:

弱监督学习提供了一种可行的解决方案,以克服SFX数据处理中的数据注释瓶.
这种方法可以使机器学习更容易获得和更有效地分析大规模的晶体数据集.

更多相关视频

Lipidico Injection Protocol for Serial Crystallography Measurements at the Australian Synchrotron

Lipidico Injection Protocol for Serial Crystallography Measurements at the Australian Synchrotron

Published on: September 23, 2020

$Microcrystallography of Protein Crystals and In Cellulo Diffraction$

Microcrystallography of Protein Crystals and In Cellulo Diffraction

Published on: July 21, 2017

相关实验视频

Last Updated: Jul 12, 2025

$Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography$

Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography

Published on: April 24, 2018

Lipidico Injection Protocol for Serial Crystallography Measurements at the Australian Synchrotron

Lipidico Injection Protocol for Serial Crystallography Measurements at the Australian Synchrotron

Published on: September 23, 2020

$Microcrystallography of Protein Crystals and In Cellulo Diffraction$

Microcrystallography of Protein Crystals and In Cellulo Diffraction

Published on: July 21, 2017