不孕症的类型和先天性形的患病率
Olga Basso1,2,3, Gabriel D Shapiro2,3, Robert Gagnon1,2
1Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Paediatric and perinatal epidemiology
|October 20, 2023
概括
父母的排卵障碍与孩子患先天性形的风险更高有关,即使没有辅助生殖技术. 这一发现强调了在评估出生缺陷风险时考虑不孕不育原因的重要性.
科学领域:
- 生殖医学 生殖医学
- 儿科健康 儿科健康
- 临床流行病学临床流行病学
背景情况:
- 通过辅助生殖技术 (ART) 或经过长时间延误怀孕的儿童表现出先天性形率的增加.
- 不同不孕症原因对形患病率的具体影响仍未得到充分研究.
研究的目的:
- 量化各种不孕不育原因与先天性形的患病率之间的联系.
- 根据不孕症诊断和治疗类型区分风险,包括ART.
主要方法:
- 在1996-2017年间,对6,656名出生于不孕不育的父母的儿童 (暴露) 和10,382名出生于不孕不育的父母的儿童 (参考) 的比较研究.
- 计算了所有被诊断为2岁以下的严重形的患病率和差异,按不孕不育状态,治疗和诊断分层.
- 对所有儿童进行了分析,特别是对单身儿童进行了分析.
主要成果:
- 患有不孕症父母的孩子表现出更高的发育不良患病率,特别是在ART怀孕后.
- 排卵障碍与所有形 (PR 1.49) 和严重形 (PR 1.53) 在没有治疗的怀孕中增加的患病率有关.
- 无法解释的不孕不育和男性因子不孕不育也与分别所有和严重发育不良的风险更高有关.
结论:
- 排卵障碍始终与先天性形的更高患病率有关,包括严重的病例,在活产儿中.
- 这种关联不管受孕方式如何,都适用,强调了基础不孕症诊断的作用.
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