患有阿片类药物使用障碍的孕妇患者的患者导航:随机多站点试验试验结果
Gerald Cochran1,2, Marcela C Smid3, Elizabeth E Krans4
1Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Addiction (Abingdon, England)
|October 20, 2023
概括
患者导航 (PN) 改善了阿片类药物使用障碍 (OUD) 的孕妇的治疗坚持. 这项试点研究证明了PNN.
科学领域:
- 产科和妇科 产科和妇科
- 成 药物 药物 药物 药物
- 公共卫生 公共卫生
背景情况:
- 孕妇的阿片类药物使用障碍 (OUD) 对母亲和孩子都有风险.
- 患者导航 (PN) 可能会改善OUD孕妇的治疗坚持和参与.
- 现有的研究需要探索PN干预措施在这个人群中的可行性和有效性.
研究的目的:
- 检查参与者招生,会议交付和PN干预评估的可行性.
- 为了比较PN与常规护理 (UC) 在孕妇OUD治疗参与的初步有效性.
- 评估与OUD (MOUD) 使用药物相关的结果,物质使用障碍 (SUD) 治疗出席率和过量服用.
主要方法:
- 一个试点,单盲,多地点随机试验,涉及102名OUD孕妇成年人.
- 参与者被随机分配到10次产前和4次产后PN干预或UC.
- 通过同意,会议交付和评估完成率来评估可行性;使用混合效应模型分析有效性.
主要成果:
- 该PN干预表明了良好的可行性,87%的同意率和高评估完成率.
- 与UC相比,PN参与者表现出更好的MOUD坚持,SUD治疗出席率,以及减少非处方阿片类药物的使用.
- 产后不孕症与产后2个月和6个月过量事件的显著减少有关.
结论:
- 患者导航是改善孕妇OUD治疗参与度的可行和潜在有效的干预措施.
- 普尼与更好地遵守OUD的药物治疗以及减少物质使用和过量服用有关.
- 这些发现支持需要进行大规模试验,以进一步验证PN对这一群体的益处.
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