胎儿中枢神经系统形与修改的心肌性能指数之间的关系
Gokce Naz Kucukbas1, Mustafa Bağcı2, Hanım Güler Şahin2
1Obstetrics and Gynecology/Perinatology, Kocaeli City Hospital, Kocaeli, TUR.
Cureus
|October 20, 2023
概括
胎儿中枢神经系统 (CNS) 异常与产前心脏功能障碍有关,由更高的修饰肌心性能指数 (mMPI) 表示. 这种关联似乎独立于特定的中枢神经系统形类型.
科学领域:
- 周围生理学 周围生理学
- 胎儿心脏病学 胎儿心脏病学
- 神经发育儿科 神经发育儿科
背景情况:
- 胎儿腹腔巨变是一种常见的中枢神经系统 (CNS) 异常,与心肌功能指数 (mMPI) 的升高相关.
- 其他中枢神经系统病理对胎儿心脏功能的影响,特别是mMPI,仍未得到充分研究.
- 这项研究探讨了各种胎儿中枢神经系统病理和心脏表现之间的关系.
研究的目的:
- 研究被诊断患有中枢神经系统 (CNS) 病理的胎儿心肌性能指数 (mMPI) 的变化.
- 要确定除先天性心脏病外的中枢神经系统异常是否会影响胎儿的心脏功能.
- 评估不同类型的中枢神经系统形和心脏表现之间的相关性.
主要方法:
- 研究了126名孕妇的队列,其中63名胎儿表现出中枢神经系统异常 (,无脑,脑,丹迪-沃克形,水,脑).
- 为了进行比较,包括63名健康,妊娠年龄匹配的胎儿的对照组.
- 胎儿左心室mMPI在第二个三个月内通过超声波进行评估,并分析妊娠特征.
主要成果:
- 在研究组和对照组之间没有观察到怀孕特征的显著差异.
- 与对照组相比,中枢神经系统形的胎儿的mMPI平均值明显高 (0.45±0.04对比0.39±0.02,P<0.001).
- 在中枢神经系统形组中,有封闭和开放形缺陷的胎儿之间的平均mMPI可比.
结论:
- 胎儿中枢神经系统 (CNS) 异常与产前心脏功能障碍有关.
- 中枢神经系统异常与心脏功能障碍之间的这种关联可能独立于特定类型的中枢神经系统形.
- 这些发现表明神经发育与子宫内心脏表现之间存在潜在的联系.
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