患有妊娠前症的母亲出生的有风险儿童的血管结构和功能的决定因素 (FINNCARE研究)
Michelle Renlund1,2, Tiina Jääskeläinen3,4, Anni Kivelä3
1Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Frontiers in cardiovascular medicine
|October 20, 2023
概括
暴露于子宫前 (PE) 的儿童表现出正常的外周动脉内心介质厚度,但与血压相关. 肥胖与动脉硬有关,这表明PE暴露儿童的早期心血管疾病进展.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 血管生物学 血管生物学
- 产科 产科 产科 产科 产科
背景情况:
- 孕前 (PE) 与儿童血压升高有关.
- 调查PE对儿童动脉健康的影响对于早期发现心血管疾病至关重要.
研究的目的:
- 为了确定暴露于PE的儿童的高血压是否反映在他们的动脉健康上.
- 检查人体测量,人体构成和围产期因素对暴露于PE的儿童动脉健康的影响.
主要方法:
- 对182名暴露于PE和85名不暴露的8至12岁儿童进行前性队列研究.
- 使用超高频超声波,门诊血压,身体组成和度学衍生的脉冲波速度 (PWV) 评估动脉健康状况.
主要成果:
- 动脉内心介质厚度 (IMT),动脉厚度 (AT) 或光直径 (LD) 在两组之间没有差异.
- 周围动脉IMT与24小时的缩血压和脉冲压,PWV和人体测量 (瘦体质量) 相关.
- 肥胖与局部动脉硬性,延展性和壁面压力独立相关.
结论:
- 暴露于PE儿童的外周动脉IMT与对照组相似,但与BP相关.
- 肥胖与动脉硬相关,表明PE暴露儿童的潜在早期心血管疾病进展.
- 孕期或围产因素与儿童血管健康参数没有显著的关联.
关键词:
在Adventitia的厚度上.动脉健康 动脉健康血压 血压 血压 血压心血管疾病心血管疾病冠状动脉硬度 冠状动脉硬度亲密介质的厚度.孕产妇产前炎症 (pre-eclampsia) 是一个严重的疾病.超高频超声波超高频超声波超声波超高频超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波超声波相关概念视频
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