在FTD-ALS频谱中,终身个性与临床表型之间的关联
Giulia Vinceti1,2, Chiara Carbone1, Chiara Gallingani1,2
1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Frontiers in neuroscience
|October 20, 2023
概括
患病前的个性特征可能会影响个人是否患上前性痴呆症 (FTD) 或肌缩性侧面硬化症 (ALS). 患有ALS的患者表现出更高的患病前开放性和外向性,与大脑连接性相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 前性痴呆症 (FTD) 和肌缩性侧面硬化症 (ALS) 是同一神经退行性FTD-ALS频谱的一部分.
- 确定特定表型 (FTD或ALS) 的因素仍然不清楚.
- 临床观察表明FTD和ALS患者之间的个性差异,可能早于疾病发作.
研究的目的:
- 为了调查FTD和ALS患者之间的病前人格差异.
- 探索病前个性与大脑功能组织之间的关联.
主要方法:
- 在40名患者 (27名FTD,13名ALS) 中使用NEO人格库存3 (NEO-PI-3) 评估了患病前的个性.
- 护理人员在症状出现前20年报告了患者的个性.
- 在一小组患者中利用结构性和静止状态功能性MRI (rsfMRI).
主要成果:
- 与FTD患者相比,ALS患者的预发性开放性 (p=0.01) 和外向性 (p=0.04) 显著增加.
- 与FTD患者和对照患者相比,ALS患者在 Salience 网络中表现出更大的功能连接性.
- 在所有患者中,在病前的开放性和突出的网络连接性之间发现了正相关性.
结论:
- 患病前的性格特征,特别是开放性和外向性,可能会使个人倾向于发展FTD或ALS.
- 大脑的功能连接,特别是在 Salience 网络中,与患病前的个性有关.
- 这些发现为FTD-ALS频谱中的表型差异提供了潜在的解释.
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