对疑似来自供体的感染的方法
Hannah Kinard Bahakel1, Rebecca Pellet Madan2,3, Lara Danziger-Isakov1,4
1Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Frontiers in pediatrics
|October 20, 2023
概括
在小儿固体器官移植 (SOT) 受体中预防来自捐赠者的感染至关重要. 这一审查定义了传播风险,确定了高风险的捐赠者因素,并提出了一种捐赠者接受矩阵,以改善结果.
科学领域:
- 移植免疫学 移植免疫学
- 传染病的传播是传染病的传播.
- 儿科重症监护 儿科重症监护 儿科重症监护
背景情况:
- 来自捐赠者的感染对儿科固体器官移植 (SOT) 接受者构成重大风险.
- 现有的指导方针针对预期的传播 (HIV,HBV,HCV),但意外的感染仍然是一个挑战.
- 合理的风险益处评估对于预防来自捐赠者的疾病至关重要.
研究的目的:
- 定义和区分儿科SOT的预期与未预期的疾病传播风险.
- 识别与传染意外感染风险较高相关的捐赠者特征.
- 提出接受捐赠者的决策矩阵,并讨论捐赠者查的未来方向.
主要方法:
- 关于儿科SOT中捐赠体感染的现有文献的综述.
- 分析与意想不到的疾病传播相关的供体风险因素和临床表现.
- 基于风险分层的概念矩阵的开发,以评估基于风险分层的捐赠者接受.
主要成果:
- 区分可预测的 (如HIV,HBV,HCV) 和不可预测的感染传播风险.
- 强调特定的供体呈现增加了意外疾病传播的可能性.
- 强调需要一种超越标准查协议的综合方法.
结论:
- 虽然SOT本质上带有感染传播风险,但多方面的战略可以减轻重大疾病传播事件.
- 综合性供体评估,接受者需要考虑,警的移植后监测和及时干预是关键.
- 改善供体查和风险评估对于提高儿科SOT的安全性至关重要.
更多相关视频
07:06Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
27.2K
11:59Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
Published on: September 6, 2017
7.4K
相关概念视频
Bone Marrow Sampling and Transplants
341
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
341
Kidney Transplant I: Introduction
14
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
14
Tissue Transplantation
379
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
379
Immunodeficiency Diseases
957
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
957
Blood Transfusion
581
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
581
Kidney Transplant II: Surgical Procedure
20
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
20
