1型糖尿病对线性生长的影响:综合性综述
Indrayani Jadhav1, Swarupa Chakole2
1Medicine and Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
1型糖尿病 (T1DM) 对儿童的生长产生负面影响,经常导致身高矮,特别是在女孩身上. 最佳的胰岛素治疗和新技术可能会改善受影响儿童的生长模式.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 增长和发展 增长和发展
背景情况:
- 1型糖尿病 (T1DM) 显著影响儿童的生长.
- 代谢控制和疾病持续时间是影响生长结果的关键因素.
- 患有T1DM的儿童表现出生长激素 (GH) - 胰岛素类生长因子-1 (IGF-1) 轴异常.
研究的目的:
- 审查目前对T1DM儿童身高受损的理解.
- 探索激素相互作用对T1DM生长的影响.
- 评估不同胰岛素疗法和新兴技术对生长的影响.
主要方法:
- 关于T1DM和儿科生长的研究的文献综述.
- 对激素调节生长的分析,包括GH-IGF-1和性激素轴.
- 用各种胰岛素方案和技术评估治疗结果.
主要成果:
- 患有T1DM的儿童可能会体验到更矮的身材,一些研究表明这在女孩或两性都存在.
- 男孩的最终身高保持不变,但女孩的身高略有下降.
- 胰岛素治疗,特别是青春期的良好的基础胰岛素,影响了身高,而连续的皮下胰岛素注射没有影响.
结论:
- 在儿童中,T1DM具有明显的线性生长障碍风险.
- 激素失衡,特别是涉及GH-IGF-1和性激素轴,导致生长障碍.
- 先进的胰岛素疗法和新技术对优化患有T1DM的青春期前儿童的生长有希望.
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