在摩洛哥连续五个赛季的人类呼吸道同胞病毒的循环模式和分子流行病学
Abderrahman Bimouhen1,2, Zakia Regragui2, Fatima El Falaki2
1Laboratory of Human Pathologies Biology, Faculty of Sciences Mohammed V University in Rabat Rabat Morocco.
Influenza and other respiratory viruses
|October 20, 2023
概括
在摩洛哥的呼吸道同胞性病毒 (HRSV) 监测显示,在2012-2017年间,HRSV-B是占主导地位的亚型 (61%). 在HRSV-A菌株中,ON1基因型占主导地位,而BA9在HRSV-B菌株中最常见.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 呼吸道同胞性病毒 (HRSV) 是婴儿呼吸道感染的主要原因之一.
- 了解HRSV流行率和遗传多样性对于公共卫生干预至关重要.
研究的目的:
- 调查2012年至2017年摩洛哥的HRSV流行率和特征.
- 使用部分G基因测序分析循环HRSV基因型的趋势.
主要方法:
- 从外科医生和住院患者收集了呼吸道样本,这些患者患有ILI或SARI.
- 使用RT-qPCR检测出HRSV,随后进行全基因组测序和基因组分析以确认基因型.
- 患者的年龄范围:1个月至99岁.
主要成果:
- 在3679个标本中,19.7% (726) 的检测结果为HRSV阳性.
- HRSV-B (61%) 比HRSV-A (35%) 的流行率更高.
- 基因型检测显示了HRSV-A的ON1和HRSV-B的主要BA9,BA10仅在2012年被检测到.
结论:
- 在研究期间发现的唯一HRSV基因型是BA9,BA10和ON1.
- 观察到的G基因变异表明需要对本地HRSV菌株进行持续的基因组监测.
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