在WFS1上的miR-668结合位变体rs1046322与东南亚人肥胖有关
Maha M Hammad1,2, Mohamed Abu-Farha1, Prashantha Hebbar3
1Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait, Kuwait.
Frontiers in endocrinology
|October 20, 2023
概括
沃尔夫拉姆综合征1基因 (WFS1) rs1046322变体与东南亚人肥胖有关,而不是阿拉伯人或南亚人. 这表明WFS1是WFS1.
科学领域:
- 遗传学 是一个遗传学.
- 代谢疾病 代谢疾病
- 人口健康 人口健康
背景情况:
- 沃尔夫拉姆综合征1基因 (WFS1) 与沃尔夫拉姆综合征,2型糖尿病 (T2D) 和代谢特征有关.
- 包括rs1046322在内的WFS1变体与T2D有关,具有miRNA结合位点的潜在调节.
- 以前的研究表明rs1046322影响miR-668与WFS1mRNA结合,并与匈牙利人的T2D有关.
研究的目的:
- 在科威特的一个多民族队列中调查WFS1rs1046322多态与代谢特征的关联.
- 确定种族背景是否影响WFS1 rs1046322对代谢疾病易感性的影响.
主要方法:
- 2067个来自不同种族背景 (东南亚,阿拉伯,南亚) 的个体中WFS1 rs1046322多态的基因定型.
- 进行了遗传关联测试,以分析WFS1 rs1046322 SNP与与肥胖有关的特征之间的关系.
- 应用了统计分析,包括多次测试的校正,以评估观察到的关联的意义.
主要成果:
- 在东南亚人口中,WFS1 rs1046322和肥胖特征 (BMI,腰围,甘油三) 之间发现了显著的关联.
- 在阿拉伯或南亚人群中,没有观察到rs1046322与这些特征之间的显著关联.
- 与非携带者相比,影响等位基因的东南亚携带者表现出更高的BMI,腰围和甘油三水平.
结论:
- WFS1 rs1046322多态性在肥胖中起作用,肥胖是已知的糖尿病风险因素,特别是在东南亚人口中.
- 种族背景显著影响像WFS1rs1046322这样的遗传变异对代谢疾病易感性的影响.
- 需要进一步的研究来阐明WFS1变种对代谢健康的种族特异性影响背后的机制.
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