中国社区成年人肉类病与死亡率之间的关系:一项为期7年的队列研究,采用倾向性得分匹配和门德尔随机化
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Updated: Jul 12, 2025
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The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
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Lijiao Xiong1,2, Tingfeng Liao1,2, Tianting Guo3
1Department of Geriatrics, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology), Shenzhen, China.
Frontiers in endocrinology
|October 20, 2023
概括
皮症显著增加了中国成年人的7年死亡风险. 手握力低和步行速度慢是增加风险的关键因素,强调监测这些因素的重要性.
科学领域:
- 老年学与公共卫生
- 老龄化的流行病学.
- 肌肉骨健康 肌肉骨健康
背景情况:
- 标志着肌肉质量和力量的损失的萨尔科佩尼亚与不良健康结果有关,包括死亡风险升高.
- 了解萨科佩尼亚在不同人群中的长期死亡影响对于公共卫生倡议至关重要.
- 之前的研究已经表明了sarcopenia和增加的死亡率之间的联系,但特定的人口数据和因果因素需要进一步调查.
研究的目的:
- 为了评估与社区中国人群中与肉类相关的7年死亡风险.
- 为了调查萨科佩尼亚的特定组成部分和全因死亡率之间的因果关系.
- 鉴定不同年龄组中导致死亡率的与肉症相关的关键因素.
主要方法:
- 从2011年到2018年的中国健康和退休长度研究 (CHARLS) 的数据使用长度研究 (n=9,006).
- 根据亚洲肉病工作组 (AWGS) 2019年标准进行的肉病诊断.
- 统计分析包括后勤回归,卡普兰-梅尔生存分析,倾向得分匹配和使用欧洲人口数据评估因果关系的门德尔随机化 (MR) 分析.
主要成果:
- 萨科白与显著更高的7年死亡风险相关 (OR 1.41,p < 0.05),严重的萨科白显示出更大的风险 (OR 2.11).
- 随着各个年龄组的copenia严重程度,死亡风险增加,特别明显的是45-60岁和≥80岁的年龄组,分别为copenia和严重的copenia.
- 门德尔随机化分析发现,手握力低 (在60岁以上的人群中) 和通常步行速度较慢与死亡风险增加有因果关系.
结论:
- 肉症对中国人口的生存构成重大威胁,这凸显了它对公共卫生的重要性.
- 手握力较低和步行速度减慢是肉症的关键组成部分,这大大增加了死亡风险.
- 针对肌肉力量和运动的早期识别和干预对于减轻与肉类相关的死亡率至关重要.
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