从即时释放制剂转换为延长释放制剂对移植患者功能的影响:元分析
Sheng Chao1, Lei Jia1, Kejing Zhu1
1Department of Organ Transplantation, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Frontiers in pharmacology
|October 20, 2023
概括
将移植患者从即时释放转换为延长释放的塔克罗利可能会改善功能. 这种变化,特别是随着随访时间的延长,显示了功能标志物的潜在益处.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 移植 移植 移植 移植
背景情况:
- 塔克罗利马斯配方会影响移植的结果.
- 从即时释放转换为延长释放的塔克罗利莫斯对其对功能影响有争议.
研究的目的:
- 为了比较脏功能之前和之后转换脏移植患者从立即释放到延长释放的塔克罗利木斯.
- 分析转化后血清肌素 (Scr) 和估计的淋巴细胞过率 (eGFR) 的变化.
主要方法:
- 一项对对移植患者的塔克罗利斯配方进行比较的研究的元分析.
- 搜索了PubMed,Cochrane,Embase,CNKI,CQVIP和Wanfang的数据库. 这是一个很大的问题.
- 在转换前后提取并分析Scr和eGFR数据.
主要成果:
- 纳入了10项涉及743名患者的研究.
- 转换后血清肌氨酸 (Scr) 显著下降 (MD: -8.00 μmol/L,p=0.01). 在转换后,血清肌氨酸 (Scr) 显著下降 (MD: -8.00 μmol/L,p=0.01).
- 估计的淋巴膜过率 (eGFR) 呈现上升趋势,但没有统计学意义 (MD: 2.21 mL/min/1.73 m2,p=0.26).
- 在随访≥48周的患者中观察到Scr的改善,而eGFR保持不变.
- 在随访时间小于48周的患者中,没有发现Scr或eGFR的显著变化.
结论:
- 转换为延长释放塔克罗利莫斯可能为移植接受者提供功能的一些改善.
- 潜在的益处可能与服用时间表或治疗持续时间有关.
- 进一步的研究可能会澄清延长释放配方的长期影响和最佳使用.
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