通常使用的防腐剂的TRPA1依赖和独立激活
Maximilian L Mager1, Cosmin I Ciotu1, Markus Gold-Binder1
1Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Frontiers in pharmacology
|October 20, 2023
概括
某些制药防腐剂会激活TRPA1通道,这是一个疼痛和炎症通道. 这种激活是由炎症调解剂加剧的,指导选择更安全的防腐剂用于肠道药物.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 生物化学 生物化学
背景情况:
- 防腐剂确保了亲肠道药品的微生物稳定性,特别是在多剂量配方中.
- 一些防腐剂可能会引起局部副作用,包括应用部位的疼痛.
- 短暂受体潜在氨酸1 (TRPA1) 通道与疼痛和炎症有关,并被刺激物激活.
研究的目的:
- 调查常见的药品防腐剂在激活TRPA1通道方面的潜力.
- 为了确定可能导致疼痛或炎症的防腐剂,与亲肠道药物管理相关.
主要方法:
- 对16种防腐剂进行选,以检测它们在人类TRPA1转移的HEK293t细胞中调节流入的能力.
- 在小鼠感官神经元中验证结果.
- 在有助于炎症调解剂 (血清激素,组胺,前列腺素E2) 的情况下,对防腐剂诱导的TRPA1激活的评估.
主要成果:
- 甲,甲,乙甲,甲,甲基甲,乙醇和诱导的TRPA1依赖流入防腐剂度.
- 亲炎性调解剂通过几个测试的防腐剂增强了TRPA1的激活.
- 一些防腐剂在对照细胞中增加了的流入,表明非特异性影响.
结论:
- 几种常见的防腐剂激活TRPA1通道,这是疼痛和炎症的关键参与者.
- 这些防腐剂的促炎潜力通过与炎症调解剂的同时使用而被放大.
- 研究结果支持选择TRPA1-无活性防腐剂以尽量减少疼痛和炎症,特别是那些具有潜在的抗炎性质的药物.
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